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KMID : 1134819970260050972
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 5 p.972 ~ p.977
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Effects of Conjugated Linoleic acid(CLA) on the Growth of Tumor Cells and the Production of Interleukin - 1 and Interleukin - 2
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Kim So-Hee
Kim Kwang-Hyuk
Park Kun-Young
Michael W. Pariza
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Abstract
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Conjugated dienoic derivatives of linoleic acid(CLA) are a series of positional and geometric isomers of linoleic acid which are found naturally in food, mainly dietary products and beef. We studied the effects of CLA on the growth of tumor cells and the production of interleukin -1 (IL-1) and interleukin-2(IL-2). CLA treatment markedly inhibited the growth of Yac-1 cells and sarcoma-180 cells by 99 and 82% to that of control, respectively, after four days of incubation at 37℃. To elucidate the immunological mechanism of antitumor activity of CLA, spleen cells of Balb/c mouse were exposed to 31, 63, 125, 250 ㎍ of CLA per ml for 24hrs at 37℃. The culture supernatants of CLA-exposed spleen cells reduced the production of IL-1 and IL-2 in all of the test conditions. These results indicate that the anticarcino-genic effect of CLA was mediated by the other actions rather than the production of the IL-1 or IL-2. We suggest that CLA might have an antiinflammatory effect in part due to its inhibitory action on the production of IL-1.
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KEYWORD
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conjugated linoleic acid(CLA), anticarcinogenicity, interleukin-(IL-1), interleukin-2(IL-2)
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